I am Post-Doc at the Translational Research Center of the University Hospital of Psychiatry and Psychotherapy Bern. I received PhD in Neuroscience at the University of Bern in 2012 with additional training at the Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institute in Stockholm. My research has been focused on the application of different neuroimaging modalities in diseases such as dementia, anxiety, and schizophrenia. Main topics have been memory functioning, task-related and resting-state brain activity, and modulation of brain activity using non-invasive brain stimulation.
Schwab, Simon; Afyouni, Soroosh; Chen, Yan; Han, Zaizhu; Guo, Qihao; Dierks, Thomas; Wahlund, Lars-Olof; Grieder, Matthias (2020). Functional Connectivity Alterations of the Temporal Lobe and Hippocampus in Semantic Dementia and Alzheimer’s Disease. Journal of Alzheimer's disease, 76(4), pp. 1461-1475. IOS Press 10.3233/JAD-191113
Grieder, Matthias; Homan, Philipp; Federspiel, Andrea; Kiefer, Claus; Hasler, Gregor (2020). Increased Anxiety After Stimulation of the Right Inferior Parietal Lobe and the Left Orbitofrontal Cortex. Frontiers in Psychiatry, 11(375), p. 375. Frontiers 10.3389/fpsyt.2020.00375
Kunzelmann, Katharina; Grieder, Matthias; van Swam, Claudia; Homan, Philipp; Winkelbeiner, Stephanie; Hubl, Daniela; Dierks, Thomas (2019). Am I hallucinating or is my fusiform cortex activated? Functional activation differences in schizophrenia patients with and without hallucinations. European journal of psychiatry, 33(1), pp. 1-7. Elsevier 10.1016/j.ejpsy.2018.06.002
Kunzelmann, Katharina; Meier, Lea; Grieder, Matthias; Morishima, Yosuke; Dierks, Thomas (2018). No effect of transcranial direct current stimulation of the auditory cortex on auditory-evoked potentials. Frontiers in neuroscience, 12(880) Frontiers Research Foundation 10.3389/fnins.2018.00880
Grieder, Matthias; Wang, Danny J. J.; Dierks, Thomas; Wahlund, Lars-Olof; Jann, Kay (2018). Default Mode Network Complexity and Cognitive Decline in Mild Alzheimer’s Disease. Frontiers in neuroscience, 12(770) Frontiers Research Foundation 10.3389/fnins.2018.00770
Andreotti, Jennifer; Dierks, Thomas; Wahlund, Lars-Olof; Grieder, Matthias (2016). Diverging Progression of Network Disruption and Atrophy in Alzheimer’s Disease and Semantic Dementia. Journal of Alzheimer's disease, 55(3), pp. 981-993. IOS Press 10.3233/JAD-160571
Grieder, Matthias; König, Thomas; Kinoshita, Toshihiko; Utsunomiya, Keita; Wahlund, Lars-Olof; Dierks, Thomas; Nishida, Keiichiro (2016). Discovering EEG resting state alterations of semantic dementia. Clinical neurophysiology, 127(5), pp. 2175-2181. Elsevier 10.1016/j.clinph.2016.01.025
Koenig, Thomas; Stein, Maria; Grieder, Matthias; Kottlow, Mara (2014). A tutorial on data-driven methods for statistically assessing ERP topographies. Brain topography, 27(1), pp. 72-83. Springer 10.1007/s10548-013-0310-1
Grieder, Matthias; Crinelli, Raffaella M; Jann, Kay; Federspiel, Andrea; Wirth, Miranka; Koenig, Thomas; Stein, Maria; Wahlund, Lars-Olof; Dierks, Thomas (2013). Correlation between topographic N400 anomalies and reduced cerebral blood flow in the anterior temporal lobes of patients with dementia. Journal of Alzheimer's disease, 36(4), pp. 711-731. Amsterdam: IOS Press 10.3233/JAD-121690
Grieder, Matthias; Crinelli, Raffaella M; Koenig, Thomas; Wahlund, Lars-Olof; Dierks, Thomas; Wirth, Miranka (2012). Electrophysiological and behavioral correlates of stable automatic semantic retrieval in aging. Neuropsychologia, 50(1), pp. 160-71. Oxford: Elsevier 10.1016/j.neuropsychologia.2011.11.014
Conference or Workshop Item
Grieder, Matthias (4 November 2017). Unexpected CBF response to anxiety reinforcing transcranial direct current stimulation (Unpublished). In: Organisation for Human Brain Mapping: 3rd Alpine Chapter Symposium. Bern. 03.11.2017-04.11.2017.
Grieder, Matthias; Müller, Sarah Maria; Winkelbeiner, Stephanie; Dierks, Thomas (8 September 2017). Bilateral temporal tDCS enhances sleep-dependent episodic memory consolidation (Unpublished). In: Clinical Neuroscience Bern: 12th Annual Meeting. Bern. 08.09.2017.
Grieder, Matthias; Mueller, Sarah Maria; Winkelbeiner, Stephanie; Dierks, Thomas (25 June 2017). Bilateral temporal tDCS enhances sleep-dependent episodic memory consolidation (Unpublished). In: OHBM Annual Meeting 2017. Vancouver, Canada. 25.06.2017-29.06.2017.
Grieder, Matthias; Wang, Danny JJ; Dierks, Thomas; Wahlund, Lars-Olof; Jann, Kay (25 June 2017). Local signal complexity and dynamic functional connectivity associated with Alzheimer’s severity (Unpublished). In: OHBM Annual Meeting 2017. Vancouver, Canada. 25.06.2017-29.06.2017.
Grieder, Matthias (2 December 2016). tDCS-methodology, application and available results (Unpublished). In: BENESCO lecture series 2016/17. Bern. 02.12.2016.
Schwab, Simon; Wahlund, Lars-Olof; Dierks, Thomas; Grieder, Matthias (27 June 2016). Contralateral functional connectivity of temporal lobes in Alzheimer’s disease and semantic dementia (Unpublished). In: OHBM 2016 Annual Meeting. Genf. 26.06.-30.06.2016.
Grieder, Matthias; Crinelli, Raffaella M.; Jann, Kay; Federspiel, Andrea; Wirth, Miranka; König, Thomas; Stein, Maria; Wahlund, Lars-Olof; Dierks, Thomas (2013). Altered N400 correlates with reduced neuronal activity in anterior temporal lobes in dementia. Clinical EEG and neuroscience, 44(4), E96. Sage
Grieder, Matthias; Dierks, Thomas; Stein, Maria; Wirth, Miranka; Crinelli, Raffaella; Wahlund, Lars-Olof; Francisco, Lacerda (1 October 2010). Altered Electrophysiology of Semantic Word Processing in Alzheimer's Disease and Semantic Dementia. Clinical EEG and neuroscience, 41(4), p. 235. Sage 10.1177/155005941004100411
Grieder, Matthias; Crinelli, Raffaella; Dierks, Thomas; Wahlund, Lars-Olof; Wirth, Miranka (20 March 2009). Does Age Matter? Semantic Memory in Healthy Young and Elderly Adults. Neuropsychobiology, 59(2), pp. 59-79. Basel: Karger 10.1159/000209314
Grieder, Matthias (2012). Event-relating to potential dementia. Semantic processing in the course of healthy and pathological aging. (Dissertation, University Hospital of Psychiatry, Department of Psychiatric Neurophysiology)
I am interested in the neuronal mechanisms of memory and the neuropathology of memory impairments. I see this field as crucial for the understanding of several psychiatric diseases such as dementia, schizophrenia, and depression, as well as for their treatment. In the case of dementia, no effective treatment has been discovered so far, the need to improve the understanding of the course of neurodegeneration in relation to the symptomatology is eminent. To this end, I investigated semantic memory processing in healthy aging and in patients with Alzheimer’s disease and semantic dementia. Moreover, I have been working on studies that focus on structural and functional connectivity of memory brain networks in these patient groups. More recently, I have been investigating the role of sleep architecture and memory consolidation, because, memory impairments often accompany the main symptoms of psychiatric patients. Thus, it is probable that memory disturbance is related to abnormal sleep that is frequently reported by patients. This is supported by evidence showing that deep sleep is relevant for the process that stores the daily experiences into long-term memory. Consequently, I aim at improving sleep dependent memory consolidation with the use of the non-invasive transcranial direct current stimulation, by enhancing the specific brain activity, which is related to memory performance. Finally, another current research focus lies on the identification of brain networks for anxiety memory, which are related to psychosis and chronic anxiety.