Selected Publications:
2026
Rabl M, Zullo L, Wehrli J, Hössel K, Lewczuk P, Petkov Peyneshki I, Seifritz E, Klöppel S, von Gunten A, Popp J. Omics-AD-A multimodal biomarker study on cognitive decline and neuropsychiatric symptoms: Design and cohort characteristics. J Alzheimers Dis. 2026 Jan;109(2):889-901. doi: 10.1177/13872877251401159. Epub 2025 Dec 4. PMID: 41342674; PMCID: PMC12775174.
2025
Brill E, Vinay R, Nißen M, Joshi P, Klöppel S, Kowatsch T. Toward a Smartphone-Based and Conversational Agent-Delivered Just-in-Time Adaptive Holistic Lifestyle Intervention for Older Adults Affected by Cognitive Decline: Two-Week Proof-of-Concept Study. JMIR Form Res. 2025 Jul 28;9:e66885. doi: 10.2196/66885. PMID: 40720890; PMCID: PMC12303554.
Ferrandez Y Montesinos M, Guerchouche R, Lemaire J, Brill E, Klöppel S, Bremond F, Solari F, Robert P, Sacco G, Manera V. Feasibility and acceptability of a remote computerized cognitive training employing telehealth in older adults with subjective cognitive complaints. Digit Health. 2025 Mar 25;11:20552076251324015. doi: 10.1177/20552076251324015. PMID: 40144050; PMCID: PMC11938904.
Lahr J, Schulze N, Wüst LN, Beisbart C, Bruhin LC, Ienca M, Nef T, Trachsel M, Klöppel S. Ethics of Sensor-Based Surveillance of People with Dementia in Clinical Practice. Sensors (Basel). 2025 Apr 2;25(7):2252. doi: 10.3390/s25072252. PMID: 40218764; PMCID: PMC11990963.
2024
Klöppel S, Brill E, Frisoni GB, Aarsland D, Klusmann-Weißkopf V. Value-based motivational strategies combined with technology to encourage a lifestyle that helps to prevent dementia. Lancet Healthy Longev. 2024 Jun;5(6):e443-e446. doi: 10.1016/S2666-7568(24)00069-2. PMID: 38824958.
Brill E, Holfelder A, Falkner M, Krebs C, Brem AK, Klöppel S. Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial. BJPsych Open. 2024 Nov 6;10(6):e200. doi: 10.1192/bjo.2024.797. PMID: 39501844; PMCID: PMC11698156.
Lenouvel E, Tobias S, Mühlbauer V, Dallmeier D, Denkinger M, Klöppel S, Schönfeldt-Lecuona C. Antidepressants for treating depression among older adults with dementia: A systematic review and meta-analysis. Psychiatry Res. 2024 Oct;340:116114. doi: 10.1016/j.psychres.2024.116114. Epub 2024 Jul 31. PMID: 39163819.
2023
Krebs C, Brill E, Minkova L, Federspiel A, Kellner-Weldon F, Wyss P, Teunissen CE, van Harten AC, Seydell-Greenwald A, Klink K, Züst MA, Brem AK, Klöppel S. Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline. J Alzheimers Dis. 2023;93(1):107-124. doi: 10.3233/JAD-221001. PMID: 36970895; PMCID: PMC10200167.
Krebs C, Peter J, Brill E, Klöppel S, Brem AK. The moderating effects of sex, age, and education on the outcome of combined cognitive training and transcranial electrical stimulation in older adults. Front Psychol. 2023 Sep 22;14:1243099. doi: 10.3389/fpsyg.2023.1243099. PMID: 37809311; PMCID: PMC10556861.
Lenouvel E, Ullrich P, Siemens W, Dallmeier D, Denkinger M, Kienle G, Zijlstra GAR, Hauer K, Klöppel S. Cognitive behavioural therapy (CBT) with and without exercise to reduce fear of falling in older people living in the community. Cochrane Database Syst Rev. 2023 Nov 15;11(11):CD014666. doi: 10.1002/14651858.CD014666.pub2. PMID: 37965937; PMCID: PMC10646947.
Klöppel S, Gunten AV, Georgescu D. Qualitätsstandards in der Alterspsychiatrie [Quality Standards in Old Age Psychiatry]. Praxis (Bern 1994). 2022 Sep;111(12):660-666. German. doi: 10.1024/1661-8157/a003896. PMID: 36102019.
Zeller CJ, Züst MA, Wunderlin M, Nissen C, Klöppel S. The promise of portable remote auditory stimulation tools to enhance slow-wave sleep and prevent cognitive decline. J Sleep Res. 2023 Aug;32(4):e13818. doi: 10.1111/jsr.13818. Epub 2023 Jan 11. PMID: 36631001.
2022
Brill E, Krebs C, Falkner M, Peter J, Henke K, Züst M, Minkova L, Brem AK, Klöppel S. Can a serious game-based cognitive training attenuate cognitive decline related to Alzheimer's disease? Protocol for a randomized controlled trial. BMC Psychiatry. 2022 Aug 12;22(1):552. doi: 10.1186/s12888-022-04131-7. PMID: 35962371; PMCID: PMC9373273.
2021
Krebs C, Peter J, Wyss P, Brem AK, Klöppel S. Transcranial electrical stimulation improves cognitive training effects in healthy elderly adults with low cognitive performance. Clin Neurophysiol. 2021 Jun;132(6):1254-1263. doi: 10.1016/j.clinph.2021.01.034. Epub 2021 Mar 26. PMID: 33875372.
2020
Krebs C, Klöppel S, Heimbach B, Peter J. Education moderates the effect of tDCS on episodic memory performance in cognitively impaired patients. Brain Stimul. 2020 Sep-Oct;13(5):1396-1398. doi: 10.1016/j.brs.2020.07.008. Epub 2020 Jul 23. PMID: 32712342.
Boillat M, Annoni JM, Démonet JF, Allali G, Felbecker A, Gietl A, Klöppel S, Monsch A, Sacco L, Sollberger M, Frisoni GB. Le Registre suisse pour la santé du cerveau - Une infrastructure nationale pour la recherche sur la maladie d’Alzheimer [The Swiss Brain Health Registry : a national infrastructure for Alzheimer's research]. Rev Med Suisse. 2021 Dec 15;17(763):2202-2205. French. PMID: 34910407.
Wunderlin M, Züst MA, Hertenstein E, Fehér KD, Schneider CL, Klöppel S, Nissen C. Modulating overnight memory consolidation by acoustic stimulation during slow-wave sleep: a systematic review and meta-analysis. Sleep. 2021 Jul 9;44(7):zsaa296. doi: 10.1093/sleep/zsaa296. PMID: 33406249.
